When you think of futuristic medical treatment, the images that pop into your mind are probably along the lines of organs grown in a petri dish or fancy high-tech equipment. I bet you don’t think of poop being taken from one person and given to another, but that is where the future of gastrointestinal treatment (and possibly treatment of many other diseases) is headed. Fecal microbiota transplantation (FMT), also called fecal bacteriotherapy, is not a new concept. People all over the world have been using variations of it for centuries, but it’s only in recent years that modern medicine has begun to embrace it and really attempt to get to the bottom of it. Let’s try and get over the initial yuck factor and dive into why this treatment is actually quite awesome.
Fig 1. “Stool sample” photo taken by Emily S. Melzer
Before we talk about the procedure, let’s back up and go over the term “normal flora” or “microbiota”. All animals have many microbes living in and on them, and humans are no exception. The estimate used to be that for every human cell in the body there were 10 non-self microbial cells. However, that number is most likely closer to a ratio of 1:1 . Just to put this into perspective, a normal human gut has between 500-1000 different bacterial species! You may already know that most of these microorganisms mean us no harm, and in fact do us a whole lot of good. From battling harmful disease-causing microbes (pathogens) and assisting in digestion, to maintaining a healthy immune system and producing vitamins for us – these microbes are mostly friends, not foe.
The tricky part is that our body is a complex ecosystem, where there are both good and bad players and balance is everything. How many cells we have of each species is critical to an individual’s health. There are many factors that affect this balance, including diet, antibiotic treatment, genetic factors, hygiene, and certain diseases. A microbial imbalance is termed “dysbiosis” and may result in the bad bacteria winning over the good bacteria, which may cause complications such as inflammatory bowel disease, obesity, diabetes and many other disorders .
What can be done to get a microbial community back on track? When a patient has a dysfunctional kidney and needs a replacement, we find a kidney donor. And when a patient has a pathogenic microbial hostile takeover, we look for someone to donate… microbes. But how does one do that? As gross as it may sound, one of the most effective ways to treat a patient’s imbalanced gastrointestinal tract is with a fecal transplant. If you’re thinking ‘ew, disgusting!’ that’s ok, just keep reading.
First of all, since the risks of a transplant can be very high and pathogens might end up being transferred from the donor to the recipient, donor screening is an extremely rigorous process. Donors may be relatives, friends, or strangers. Although researchers have shown that treatment tends to be slightly more effective when the donor is a partner or a close relative who shares the same environment . The general idea is that the donor’s stool is diluted with saline, mixed together and then filtered to get rid of particulates. The delivery method varies and can either be through the lower gastrointestinal tract using colonoscopy, or it could be nasogastric, which means using a tube that goes through the nose to the upper gastrointestinal tract. Alternatively, there have been attempts to deliver the microbial transplanted community in a pill that the patient can ingest .
Fig. 2. Human gastrointestinal tract (Source: Wikipedia)
This sounds nuts, could it really work? Let’s look at the example of Clostridium difficile infection. Infection by this bacterium may cause inflammation of the large intestine and is potentially fatal. In 2010 C. difficile infections killed 15,000-20,000 people in the U.S. alone and infection numbers are on the rise, partly because drug resistance is becoming more prominent. While other treatments for this disease are failing, FMT has shown to be extremely effective with a cure rate of over 90%, for the most part after a single treatment .
Fig. 3. Clostridium difficile spores. (Source: Wikipedia)
At the moment, the FDA regards FMT an experimental drug, and additional research is needed in order to standardize the procedure, as well as possibly expand its use to treat other disorders such as autoimmune diseases. Feces is something we don’t really like to talk about (unless you’re five years old and it’s a potty joke) but hopefully we can look past that and appreciate the power that our microbial community has on our health and how brilliant it is that we can share these communities to cure serious disease. This is the perfect example of the cheesy old saying “a candle loses nothing by lighting another candle”. Those with healthy microbiota have pretty much endless supplies of poop to donate to those in need of FMT and we should not only give a s**t but also be excited about this easy, low risk, inexpensive and effective treatment.
Sender, R., Fuchs, S., & Milo, R. (2016). Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell, 164(3), 337-340. http://www.cell.com/cell/pdf/S0092-8674%2816%2900053-2.pdf
Choi, H. H. and Cho, Y. S. (2016). Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clin Endosc. DOI: http://dx.doi.org/10.5946/ce.2015.117
Biliński J, Grzesiowski P, Muszyński J, Wróblewska M, Mądry K, Robak K, Dzieciątkowski T, Wiktor-Jedrzejczak W, Basak GW. (2016). Fecal Microbiota Transplantation Inhibits Multidrug-Resistant Gut Pathogens: Preliminary Report Performed in an Immunocompromised Host. Arch Immunol Ther Exp. DOI 10.1007/s00005-016-0387-9
Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., … Surawicz, C. (2011). Treating Clostridium difficile Infection with Fecal Microbiota Transplantation. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association, 9(12), 1044–1049. http://doi.org/10.1016/j.cgh.2011.08.014
More From Thats Life [Science]
- Biology Superpowers: X-Ray Vision
- How to Expand Your Senses by Reading a Blog Post
- What's up with bat echolocation?
- Seeing is Believing - How Can We Visualize Tiny Colorless Bacteria?
- Saving water is no longer a matter of how short our showers are · Water balance in a man-made world
- Double Digestion in Rabbits · Why Does Mopsy Eat Her Own Poop?
- Should I say sex or gender? Pt. 2
- Should I say sex or gender? Pt. 1
- How To Catch Hard-to-Catch Fish?
- Finding the Perfect Partner
- Is your gut trying to kill your resolve? · Mind over microbe
- Why Do Mothers Mother?
- GMO! The Places You'll Go!
- New-Fangled Paleontology · Really Old Fossils, Really Strong Predators, and Cool New Tech
- A Brief History of Evolutionary Thought, part III
- Saving face: transplanting our most distinctive features
- A Brief History of Evolutionary Thought, part II
- DNA as a solution for data storage · DNA - Nature’s Hard Drive
- A Crash Course in the Coolness of Mitochondria · Mitochondria: The Underrated Organelles
- A Pollinator’s Job Description and Why We Should All Care About Them · Pollination 101
- You May Say I’m Biased, But I’m Not the Only One
- The evolution of one of the greatest medical discoveries in history. · The Path of Least Resistance: Our Relationship with Antibiotics
- Mother Nature’s History Book · Estimating the Age of Life Long-Gone
- Proprioception as a vital sense · Know Your Limb-its
- Man’s Best Artificially-Selected Friend · Your Dog is a GMO Wolf
- Better Safe Than Sorry: The Pesticide Industry is Getting a Revamp
- Sometimes scientists have to get creative in order to effectively do science – especially on a budget. · The Bizarre Shopping List of a Determined Scientist
- Insects Get Sick Too: The Study of Insect Pathology
- Our teeny tiny friends and their huge potential · Employee of the Month - Hire a Microbe to Do Your Work
- A Brief History of Evolutionary Thought - Part I
- The Effects of Custom Build Paradise · Artificial Islands
- To B(PA) Or To Not B(PA): Regulating Endocrine Disruptors
- Bioluminescence truly looks like it is nothing short of sorcery, and although this naturally occurring phenomenon is well studied and explained, that does not take away from its beauty. · Fireflies of the Ocean: Lighting up the Dark with Science
- Part II - Cases of altruism in the animal kingdom · Charity cases in nature - when are animals more likely to be altruistic?
- Part I - Why true altruism is a rare behavior in the animal kingdom · Being selfish means staying alive
- Penguins and other strange things we study from space
- Pseudoreplication and the Art of Biological Statistics
- What is wrong with my tomatoes?...And other plant disease questions · Why did orange prices increase?
- How fecal microbiota transplants can improve lives and possibly save them · The Wonders of Fecal Transplants
- The scientific facts behind the safety and efficacy of childhood vaccines · Calling the Shots - Discussing Vaccines
- 3D Printing for Fun and Science
- What is wrong with my tomatoes?...And other plant disease questions · What is Phytopathology?
- Medical Mysteries Still Surrounding Zika Virus
- More ›